Posted: July 25th, 2017

A 43-year-old man has a 1-day history of fever and increasing headache, irritability, photophobia, and lethargy. Physical examination shows neck stiffness. Cerebrospinal fluid (CSF) shows 76,000 neutrophils/mm3 , occasionally with intracytoplasmic gram-positive cocci. Which of the following substances is most responsible for the CSF neutrophil count?

A 43-year-old man has a 1-day history of fever
and increasing headache, irritability,
photophobia, and lethargy. Physical examination
shows neck stiffness. Cerebrospinal fluid (CSF)
shows 76,000 neutrophils/mm3
, occasionally
with intracytoplasmic gram-positive cocci.
Which of the following substances is most
responsible for the CSF neutrophil count?
(A) Bradykinin
(B) C5a
(C) Factor XII (Hageman factor)
(D) Histamine
(E) Leukotriene E4