Posted: September 13th, 2017

Bioinformatics

Paper, Order, or Assignment Requirements

Biology can be seen as an information transfer chain, it is our business to deal with this information in all its biological encoding and higher order significance. The ‘central dogma’ is the key information pathway in biology as shown in Figure.
These three biological molecules form the basis for much of bioinformatics, therefore understanding the importance, use and storage of this data is essential. This chart, in Q1 you can use as reference for later work in the course or future research.
Q1. Complete the chart on the following page (Table 1). In each of the blank sections fill the following (8 Marks)
a) Provide a brief description of each molecule in question. What is their role and importance in the central dogma?
b) List 3 primary data resources (Biological databases) for each molecule with their respective URLs.
c) State 3 types of analysis those are appropriate to the molecule from the Bioinformatics viewpoint.
e.g. sequence alignment,
d) List one tools for each analysis listed with their respective URLs.
e.g. BLASTN for DNA alignment.
Q2. Bioinformatics is an intelligent method for obtaining biological knowledge using computational techniques. In this question you will execute a workflow to produce a biological outcome.
(12 Marks)
We will investigate Leukaemia in humans with reference to the B-cell lymphoma 2 (BCL 2) group of protein.
a) Using the NCBI Gene Database, investigate BCL 2: search ID PPP1R50. This display has a lot of information, list the information you infer about the particular gene.