Posted: February 19th, 2015

C-myc gene can be used as cancer biomarker

C-myc gene can be used as cancer biomarker

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The discussion is based on the result that is going to be attached

Harvard style

2000 words

Results:
Data result below is based on the data extracted from: https://gexc.stanford.edu/model/7/gene/MYC.

By using Minitab and applied Mann Whitney Test to compare between the present of myc in normal cell and cancerous cell, it was obtained the result below:
Descriptive Statistics: Normal Cells, Cancer Cells

Variable       N   N*   Mean  SE Mean  StDev  Minimum     Q1  Median      Q3
Normal Cells  11   0  7.787    0.304  1.007    6.030  6.910   7.840   8.410
Cancer Cells  11   0  9.743    0.390  1.294    8.100  8.600   9.480  11.130

Variable      Maximum
Normal Cells    9.690
Cancer Cells   11.550

Mann-Whitney Test and CI: Normal Cells, Cancer Cells

N  Median
Normal Cells  11   7.840
Cancer Cells  11   9.480

Point estimate for ETA1-ETA2 is -1.860
95.1 Percent CI for ETA1-ETA2 is (-3.050,-0.740)
W = 79.0
Test of ETA1 = ETA2 vs ETA1 not = ETA2 is significant at 0.0020

Figure 1: shows the different level of myc between normal cell and cancer cell in Haematopoietic

The data below extracted from: http://www.ebi.ac.uk/gxa/query?geneQuery=MYC
Descriptive Statistics: Normal, Cancer

Variable  N   N*   Mean  SE Mean  StDev  Minimum     Q1  Median     Q3  Maximum
Normal    8   0   16.00     3.05   8.62    2.00   11.75   14.50   22.25    31.00
Cancer    8   0   55.75     8.22  23.26    30.00  39.25   45.50   78.25    95.00

Mann-Whitney Test and CI: Normal, Cancer

N  Median
Normal  8   14.50
Cancer  8   45.50

Point estimate for ETA1-ETA2 is -32.50
95.9 Percent CI for ETA1-ETA2 is (-65.99,-18.99)
W = 37.0
Test of ETA1 = ETA2 vs ETA1 not = ETA2 is significant at 0.0014
The test is significant at 0.0013 (adjusted for ties)

Figure2: shows the level of myc expression in normal and cancerous cell

The data below extracted from:                                                                                      http://www.genecards.org/cgi-bin/carddisp.pl?

gene=MYC&bioalma_dis=91#novoseek_dis

Figure 3: shows the high level for myc expression present in different type of cancer

The data below extracted from: http://biogps.org/#goto=genereport&id=4609

Figure 4: shows the high expression of myc in different type of cancerous cell

Discussion:  I need to write the discussion wit
The overall outcome of this study shows that, myc express highly in most of cancer comparing to the normal. From the statistical test (Mann Whitney –Test) the p

value is 0.002 which is less than 0.05 and the null hypothesis is rejected. This can show the level of myc oncogene over expressed in cancer is higher than normal

subject.   Expand the point and use support evidence and examples from scientific article

Write about this point IF myc gene is detected in immune cells could be less strong biomarker but it can be detected from blood serum is a good biomarker because

ELISA needs to enter the nucleus.

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