Posted: February 20th, 2015

C-myc Gene can be Used as Cancer Biomarker

Paper, Order, or Assignment Requirements

 

 

The discussion is based on the result that is going to be attached
The result shows 4 graphs
graph 1 is about the comparative between normal and cancerous Haematopoietic in terms of high expression of myc gene
Graph 2 shows high expression of myc between normal and cancerous cell

Graph 3 shows the high level of myc expression in different type of cancer

Graph 4 shows the level of myc in cancerous cell
This study shows myc can be used as caner biomarker/ tumour biomarker but it can be taken from blood serum better than immune cells because Elisa test can not enter the nucleouse

Harvard style

                                                                                                                                

Support the discussion from some article from Pubmed

 

2000 words

 

 

Results:

Data result below is based on the data extracted from: https://gexc.stanford.edu/model/7/gene/MYC.

 

 

By using Minitab and applied Mann Whitney Test to compare between the present of myc in normal cell and cancerous cell, it was obtained the result below:

Descriptive Statistics: Normal Cells, Cancer Cells

 

Variable       N   N*   Mean  SE Mean  StDev  Minimum     Q1  Median      Q3

Normal Cells  11   0  7.787    0.304  1.007    6.030  6.910   7.840   8.410

Cancer Cells  11   0  9.743    0.390  1.294    8.100  8.600   9.480  11.130

 

Variable      Maximum

Normal Cells    9.690

Cancer Cells   11.550

 

 

Mann-Whitney Test and CI: Normal Cells, Cancer Cells

 

N  Median

Normal Cells  11   7.840

Cancer Cells  11   9.480

 

 

Point estimate for ETA1-ETA2 is -1.860

95.1 Percent CI for ETA1-ETA2 is (-3.050,-0.740)

W = 79.0

Test of ETA1 = ETA2 vs ETA1 not = ETA2 is significant at 0.0020

 

Figure 1: shows the different level of myc between normal cell and cancer cell in Haematopoietic

 

 

The data below extracted from: http://www.ebi.ac.uk/gxa/query?geneQuery=MYC

Descriptive Statistics: Normal, Cancer

 

Variable  N   N*   Mean  SE Mean  StDev  Minimum     Q1  Median     Q3  Maximum

Normal    8   0   16.00     3.05   8.62    2.00   11.75   14.50   22.25    31.00

Cancer    8   0   55.75     8.22  23.26    30.00  39.25   45.50   78.25    95.00

 

 

Mann-Whitney Test and CI: Normal, Cancer

 

N  Median

Normal  8   14.50

Cancer  8   45.50

 

 

Point estimate for ETA1-ETA2 is -32.50

95.9 Percent CI for ETA1-ETA2 is (-65.99,-18.99)

W = 37.0

Test of ETA1 = ETA2 vs ETA1 not = ETA2 is significant at 0.0014

The test is significant at 0.0013 (adjusted for ties)

 

Figure2: shows the level of myc expression in normal and cancerous cell 

 

 

The data below extracted from:                                                                                      org/cgi-bin/carddisp.pl?gene=MYC&bioalma_dis=91#novoseek_dis”>http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYC&bioalma_dis=91#novoseek_dis

 

 

Figure 3: shows the high level for myc expression present in different type of cancer

 

The data below extracted from: http://biogps.org/#goto=genereport&id=4609

 

Figure 4: shows the high expression of myc in different type of cancerous cell

 

Discussion:  I need to write the discussion wit

The overall outcome of this study shows that, myc express highly in most of cancer comparing to the normal. From the statistical test (Mann Whitney –Test) the p value is 0.002 which is less than 0.05 and the null hypothesis is rejected. This can show the level of myc oncogene over expressed in cancer is higher than normal subject.   Expand the point and use support evidence and examples from scientific article

 

Write about this point IF myc gene is detected in immune cells could be less strong biomarker but it can be detected from blood serum is a good biomarker because ELISA needs to enter the nucleus.

 

 

The discussion is based on the result that is going to be attached

The result shows 4 graphs

graph 1 is about the comparative between normal  and cancerous Haematopoietic in terms of high expression of myc gene

Graph 2 shows high expression of myc between normal and cancerous cell

 

Graph 3 shows the high level of myc expression in different type of cancer

 

Graph 4 shows the level of myc in cancerous cell

This study shows myc can be used as caner biomarker/ tumour biomarker but it can be taken from blood serum better than immune cells because Elisa test can not enter the nucleouse     Support the discussion

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