Posted: May 16th, 2016

Calculate the absorption and elimination rate constants, the volume of distribution and clearance of Y assuming that F, the bioavailability, is equal to 0.75.

7.    Drug Y is administered orally to a patient at a dose of 100mg and the following plasma concentrations were obtained with time:
Time (h)    0.2    0.4    1.0    2.0    3.0    4.0    6.0    8.0    10.0

Plasma Concentration (mg/L)    0.33    1.0    1.8    2.02    2.0    1.6    1.0    0.6    0.38

Calculate the absorption and elimination rate constants, the volume of distribution and clearance of Y assuming that F, the bioavailability, is equal to 0.75.
If the 100mg oral dose is repeated at 8 hourly intervals calculate the maximum, minimum and average steady-state plasma concentrations.
8.    Drug A is administered IV to a patient according to the following table:

Day    Time    Dose (mg)
1     4.00pm     80
11.00pm    160
2     7.00am    120
1.30pm     80

At 4.00pm on day 2 a plasma sample was analysed for A and a concentration of 6mg/L was obtained.
Is this measured concentration consistent with the expected value?
Volume of distribution of A is 14.5L and clearance is 40mL/min.