Posted: December 17th, 2014

Finding candidate genes using QTL analysis

Finding candidate genes using QTL analysis

Project description
Prompt is the following:
“Suppose that you wanted to find the genetic basis of why Dobermans are so mean relative to Beagles and identify a candidate gene(s). Explain in detail how you would

accomplish this task and the details of each step. In other words, trace ALL the steps that you would need to accomplish in order to create the animals and build the

tools that we used. Also, explain which brain region was involved but even more details about the region and gene(s). You may assume that Dobermans and Beagles are

fully inbred, that their genomes have been sequenced, and that you will live long enough to accomplish this study.”

*This “tool that we used”
refers to
Entrez gene
allen brain atlas
web QTL
UCSC Genome Browser
Pubmed

A little background that may help:
https://mdcune.psych.ucla.edu/modules/bioinformatics
(scroll down to DOWNLOAD BIOINFORMATICS FILES and (6) VIEW LECTURE AND LAB MATERIALS Lecture 3 ppt. and lab2lab3 should give an idea of what the professor wants)
(email me, please, and I can give the ppt walking through what he wants in the essay)

Things to touch for sure:
-How to make recombinant inbred strains
-quantify the phenotype
-removing the error variance (eg. sex, age, body weight, brain weight) and other individual differences.
-Describe and define QTL
-if you had to add information about dogs in the GENENETWORK (http://webqtl.org) (since there are no dogs), what would you have to do?
-likelihood ratio statistics
-etc. again, there’s a ppt walkthrough on what he wants included in there.
———-
Added on 17.12.2014 05:21
please see notes and the attatched lecture slides for a walkthrough of what to hit for the essay

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