Posted: July 24th, 2017

A healthy 19-year-old man receives a tetanus immunization booster prior to induction into the US Marines. Six hours later, he has pain and massive swelling at the site of injection. The following day, the skin breaks down, forming an ulcer at the site. Which of the following events plays a critical role in this reaction?

A healthy 19-year-old man receives a tetanus
immunization booster prior to induction into the
US Marines. Six hours later, he has pain and
massive swelling at the site of injection. The
following day, the skin breaks down, forming an
ulcer at the site. Which of the following events
plays a critical role in this reaction?
(A) Accumulation of mononuclear cells at
the site of antigen injection
(B) Antigen capture by Langerhans cells in
the epidermis
(C) Local fixation of complement by
preformed circulating antibodies
(D) Local release of histamine
(E) Predominant synthesis of IgM
antibodies