Posted: February 17th, 2015
A power point Presentation on a selected Disease using the following instructions:
Paper, Order, or Assignment Requirements
A power point Presentation on a selected Disease using the following instructions:
- Do a search on the drug. Find out other names for it. Answer the questions below.
- Find out the target of the drug. Is the target expressed in many parts of the body?
- How does the drug interact with its target. Is the effect inhibitory or stimulatory, is it complete or partial?
- What is the structure of the drug – is it a chemical or a protein. Provide a diagram showing the structure of the drug and if available, show how the drug interacts with its target.
- What animal model or models were used to test the efficacy of the drug, in pre-clinical trials? What proteins or family of proteins were shown to be affected in pre-clinical trials?
- Is the drug used to treat other diseases that are not related to the brain?
- What is the treatment regime for the patient i.e. the mode of delivery to the patient.
- What are the side-effects and how are they related to the molecular mechanisms that underly the drug’s efficacy.
For presentation, marks will be allocated as indicated below
- Title and outline (1-2 slides)
- Brief summary of disease being treated by nominated drug (1-2 slides) -> 10 marks
- Description of the drug – its history, structure, properties, target, how it interacts with the target. (2-4 slides) -> 20 marks
- Animal models used to test drug (1-2 slides) -> 5 marks
- Signalling pathways impacted by drug treatment (1-2 slides) -> 5 marks
- Sites of expression of drug target and implication – possible link to reported side-effects (1 slide)-> 5 marks
- Summary/conclusions (1-2 slides) -> 5 marks