Posted: June 26th, 2015

Myocardial ß2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure

Myocardial ß2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure

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Myocardial ß2-adrenoceptor gene delivery promotes coordinated cardiac adaptive remodelling and angiogenesis in heart failure

BACKGROUND AND PURPOSE
We investigated whether b2-adrenoceptor overexpression could promote angiogenesis and improve blood perfusion and left
ventricular (LV) remodeling of the failing heart.
EXPERIMENTAL APPROACH
We explored the angiogenic effects of b2-adrenoceptor overexpression in a rat model of post-myocardial infarction (MI) heart
failure (HF). Cardiac adenoviral-mediated b2-adrenoceptor overexpression was obtained via direct intramyocardial injection
4-weeks post-MI. Adenovirus(Ad)-GFP and saline injected rats served as controls. Furthermore, we extended our observation
to b2-adrenoceptor -/- mice undergoing MI.