Posted: August 17th, 2017

A patient with fungal encephalitis receiving amphotericin B complaints of fever, chills, and body aches. The nurse knows that these symptoms

A patient with fungal encephalitis receiving amphotericin B complaints of fever, chills, and body aches. The nurse knows that these symptoms
a) may be controlled by the administration of diphenhydramine (Benedryl) and acetaminophen (Tylenol) approximately 30 minutes prior to administration of the amphotericin.
Administration of amphotericin B may cause fever, chills and body aches. The administration of diphenhydramine (Benedryl) and acetaminophen (Tylenol) approximately 30 minutes prior to the administration of amphotericin B may prevent these side effects.
b) indicate renal toxicity and a worsening of the patient’s condition.
Renal toxicity due to amphotericin B is dose limiting. Monitoring the serum creatinine and blood urea nitrogen levels may alert the nurse to the development of renal insufficiency and the need to address the patients’ renal status.
c) are primarily associated with infection with Coccidioides immitis and Aspergillus.
Vascular changes are associated with C. immitis and Aspergillus Manifestations of vascular change may include arteritis or cerebral infarction.
d) indicate the need for immediate blood and cerebral spinal fluid (CSF) cultures.
Blood and CSF cultures help diagnosis fungal encephalitis.

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