Posted: December 17th, 2016

The pH changed to 6.2. What is the pKa of the second ionizable group?

A compound is known to have a free amino group with a pKa of 8.8, and one other ionizable group with a pKa between 5 and 7. To 100mL of a 0.2 M solution of this compound at pH 8.2 was added 40 mL of a solution of 0.2 M hydrochloric acid. The pH changed to 6.2. What is the pKa of the second ionizable group?