Posted: May 13th, 2015

Discuss the therapeutic potential of targeting the osteocyte for prevention of bone loss associated with osteoporosis.

Full Topic:
The most abundant cell in bone, the osteocyte, plays a central role in governing skeletal homeostasis. Discuss the therapeutic potential of targeting the osteocyte for prevention of bone loss associated with osteoporosis.

Please do not include introduction and conclusion.
Please must use primary jornal atrticle (The actual studies)
Please focus on the followings:

1. The osteocyte network ability to sense loading/unloading on the bone, detect and repair micro cracks, and role in systemic calcium/phosphate metabolism. (~100 words)

2. Powerful parathyriod hormone(PTH) (~350words)

3. Wnt (~350words)

4. bisphosphonates (~350words)

discuss specific molecular pathways as having therapeutic potential (remember to keep this discussion focussed on the role of these pathways in osteocyte function and the osteocyte’s influence on bone remodelling (osteoclasts, osteoblasts)). You can include brief comments on side effects.

keep your literature review focussed on the original question.